Study Groups
WWARN facilitates a number of collaborative Study Groups to undertake individual patient data meta-analyses to answer specific research questions about malaria treatments and antimalarial drug resistance. Gathering and combining data sets from multiple studies increases sample sizes, so that effects, including smaller effects, and effects on sub-populations can be identified with greater certainty. Working together and combining data from different regions and populations is improving our understanding of drug resistance and strengthening global efforts to control and eventually eliminate malaria.
![Dominic Chavez World Bank clinic_in_bamako](/sites/default/files/styles/standard_image_crop/public/page/clinic_in_bamako-dominic_chavezworld_bank.jpg?itok=D8rDR-D3)
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Dominic Chavez World Bank
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This Study Group aims to bring together and explore the latest evidence on the prevalence of molecular markers associated with antimalarial drug resis...
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Analysis of the effect of primaquine dose on the efficacy, safety and tolerability in patients with Plasmodium vivax malaria
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A pooled analysis assessing the effect of mg/kg dosing strategies on the risk of treatment failure in patients treated with the currently recommended ...
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Assessment of relationship between Haemoglobin (Hb) and Haematocrit (Hct) measurements.
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Pooled analyses of the efficacy and safety of single low-dose primaquine to interrupt P. falciparum malaria transmission.Data collection has closed an...
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A pooled analysis of methaemoglobin as a marker of primaquine antihypnozoite activity in Plasmodium vivax malaria
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Sub-study groups include the Artemether-Lumefantrine / ARV PK Study Group and the ACT-ARV Safety Study Group.
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The sulphadoxine-pyrimethamine (SP) resistance Data Access Group’s aim is to provide maps and open access to the most recent data on molecular markers...
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Determining what affects White Blood Cell (WBC) count at baseline and during acute phase of malaria infection.
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The Dihydroartemisinin-Piperaquine for Intermittent Preventive Treatment in Pregnancy Study Group aims to determine the safety and efficacy of intermi...
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Analysis of how age impacts the effect of primaquine dose on haematological safety in patients with Plasmodium vivax and Plasmodium ovale malaria
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The Subpatent Malaria and Pregnancy Outcome Study Group aims to explore the relationship between subpatent Plasmodium falciparum malaria inf...
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Analysis of haematological response before and after antimalarial treatment. A pooled analysis to understand the normal haematological response a...
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Baseline information on parasitological response to ACTs in AsiaA pooled analysis to assess the baseline early parasitological response after artemisi...
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Exploring the impact of malaria during pregnancy on infant anaemia, malaria, morbidity and growth – an individual participant meta-analysis.
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The paediatric single low-dose (SLD) primaquine efficacy study group aims to assess and compare the efficacy of SLD primaquine for transmission blocki...
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This is an extension of a planned dihydroartemisinin-piperaquine (DP) Safety Study Group, which aims to consider the effect of HIV disease and co-admi...
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Development of statistical methods to infer the relationship between the percentage of resistant infections, parasite clearance half-life and the prop...
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This study group aims to determine the impact of malaria in the first trimester of pregnancy on the mother and infant through individual patient data ...
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A pooled analysis that assessed the effect of various nutritional indicators in treatment outcome in children aged 6-59 months treated with artemisini...
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The AL Dose Impact Study Group was first established in 2011. The Study Group first met in December 2011 at the ASTMH Annual Meeting to discuss the St...
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Analysing PK/PD data to identify inadequate drug exposure and inform dosageA pooled lumefantrine pharmacokinetic-pharmacodynamic (PK/PD) analysis is b...
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Analysing PK/PD data to identify inadequate drug exposure and inform antimalarial dosageA pooled pharmacokinetic/pharmacodynamics (PK/PD) analysis of ...
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A population pharmacokinetic/pharmacodynamic model of pyrimethamine and sulfadoxine in participants who received either sulfadoxine-pyrimethamine (SP)...
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Effect of AS-AQ mg/kg dosing strategies on the risk of treatment failureA pooled analysis to assess the impact of weight adjusted (mg/kg) dose variati...
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Baseline information on parasitological response to ACTs in AfricaA pooled analysis to assess the baseline early parasitological response after artemi...
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A pooled analysis of Plasmodium falciparum gametocyte carriageThe purpose of this Study Group is to assess the risk factors for treatment failure asso...
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Analysis of risk factors of Plasmodium vivax early and late recurrence. Published in July 2018.
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Analysis of the consequences of symptomatic Plasmodium vivax infections on anaemia before and after antimalarial treatment
Effect of DP mg/kg dosing strategies on the risk of treatment failureA pooled analysis to assess the impact of weight adjusted (mg/kg) dose variations...
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Determining the optimal Artemether-lumefantrine antimalarial dosing for young children and pregnant women: A pharmacokinetic-pharmacodynamic meta...
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Analysing PK/PD data to identify inadequate drug exposure and inform dosageA pooled piperaquine pharmacokinetic analysed the exposure to piperaquine i...
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Role of candidate molecular markers of lumefantrine and amodiaquine resistanceThe Artesunate-Amodiaquine/Artemether Lumefantrine (AS-AQ/AL) Molecular ...
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Parasite clearance after treatment with an artemisinin monotherapy or ACTThis Study Group characterises parasite clearance stratified by location, tre...
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A pooled analysis on the relationship between K13 molecular marker and parasite clearance data. The Study Group closed to new participants in Dec...
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