Study Groups
WWARN facilitates a number of collaborative Study Groups to undertake individual patient data meta-analyses to answer specific research questions about malaria treatments and antimalarial drug resistance. Gathering and combining data sets from multiple studies increases sample sizes, so that effects, including smaller effects, and effects on sub-populations can be identified with greater certainty. Working together and combining data from different regions and populations is improving our understanding of drug resistance and strengthening global efforts to control and eventually eliminate malaria.
![Dominic Chavez World Bank clinic_in_bamako](/sites/default/files/styles/standard_image_crop/public/page/clinic_in_bamako-dominic_chavezworld_bank.jpg?itok=D8rDR-D3)
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Dominic Chavez World Bank
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The Alternative MiP Prevention Strategies (AMPS) Study Group’s aim is to determine the safety and efficacy of novel strategies for the control of mala...
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The paediatric single low-dose (SLD) primaquine efficacy study group aims to assess and compare the efficacy of SLD primaquine for transmission blocki...
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A pooled analysis of methaemoglobin as a marker of primaquine antihypnozoite activity in Plasmodium vivax malaria
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This Study Group aims to bring together and explore the latest evidence on the prevalence of molecular markers associated with antimalarial drug resis...
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Assessment of relationship between Haemoglobin (Hb) and Haematocrit (Hct) measurements.
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Development of statistical methods to infer the relationship between the percentage of resistant infections, parasite clearance half-life and the prop...
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Analysis of the effect of primaquine dose on tolerability and Plasmodium vivax recurrence.
![Pregnant woman sitting against a wall](/sites/default/files/styles/research_activity_480x270/public/migrated/images/study-groups/pregnant_woman-credit-doune_porter-gavi.jpg?itok=qdyVTfR6)
The Alternative MiP Prevention Strategies (AMPS) Study Group’s aim is to determine the safety and efficacy of novel strategies for the control of mala...
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![](/sites/default/files/styles/research_activity_480x270/public/migrated/images/study-groups/a_mother_and_her_children_myanmar._photo_tom_cheatham_world_bank_0.jpg?itok=w_6iEvLY)
Analysis of how age impacts the effect of primaquine dose on efficacy in patients with Plasmodium vivax and Plasmodium ovale malaria
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Determining the effects of pregnancy on piperaquine pharmacokinetics. The analysis aims to contribute evidence needed to inform recommendations on the...
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![photo Tran Thi Hoa, World Bank children singing in a class at a public preschool](/sites/default/files/styles/research_activity_480x270/public/2024-01/children_singing_in_a_class_at_a_public_preschool._photo_tran_thi_hoa_world_bank.jpg?itok=Xug47bn6)
Characterising the population pharmacokinetic properties of ivermectin in children and adults to inform optimal dosing of ivermectin
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Baseline information on parasitological response to ACTs in AsiaA pooled analysis to assess the baseline early parasitological response after artemisi...
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![Photo Dominic Chavez, World Bank mothers and babies in health centre. Sierra Leone](/sites/default/files/styles/research_activity_480x270/public/2024-02/mothers%20and%20babies%20in%20health%20centre.%20Sierra%20Leone%20Photo%20Dominic%20Chavez%20World%20Bank.jpg?itok=u7MzyfqY)
This study group aims to determine the impact of malaria in the first trimester of pregnancy on the mother and infant through individual patient data ...
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Analysis of how age impacts the effect of primaquine dose on gastrointestinal tolerability in patients with Plasmodium vivax and Plasmodium ovale mala...
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A meta-analysis of individual patient data (IPD) to determine the effect of antiretroviral (ARV) drug-drug interactions and HIV disease on artemether ...
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The Subpatent Malaria and Pregnancy Outcome Study Group aims to explore the relationship between subpatent Plasmodium falciparum malaria inf...
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Analysis of how age impacts the effect of primaquine dose on haematological safety in patients with Plasmodium vivax and Plasmodium ovale malaria
This is an extension of the WWARN Haemoglobin-Haematocrit Relationship in Malaria Study Group and the Antimalarial–Antiretroviral Analy...
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The overall aim of the IPTp and SP-resistance-associated mutations Study Group is to quantify how parasites with the sextuple mutant pfdhps and pfdhfr...
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A population pharmacokinetic/pharmacodynamic model of pyrimethamine and sulfadoxine in participants who received either sulfadoxine-pyrimethamine (SP)...
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Parasite clearance after treatment with an artemisinin monotherapy or ACTThis Study Group characterises parasite clearance stratified by location, tre...
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A pooled analysis that assessed the effect of various nutritional indicators in treatment outcome in children aged 6-59 months treated with artemisini...
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Baseline information on parasitological response to ACTs in AfricaA pooled analysis to assess the baseline early parasitological response after artemi...
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Effect of AS-AQ mg/kg dosing strategies on the risk of treatment failureA pooled analysis to assess the impact of weight adjusted (mg/kg) dose variati...
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The AL Dose Impact Study Group was first established in 2011. The Study Group first met in December 2011 at the ASTMH Annual Meeting to discuss the St...
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A pooled analysis of Plasmodium falciparum gametocyte carriageThe purpose of this Study Group is to assess the risk factors for treatment failure asso...
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Analysis of risk factors of Plasmodium vivax early and late recurrence. Published in July 2018.
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Analysing PK/PD data to identify inadequate drug exposure and inform dosageA pooled lumefantrine pharmacokinetic-pharmacodynamic (PK/PD) analysis is b...
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Analysing PK/PD data to identify inadequate drug exposure and inform dosageA pooled piperaquine pharmacokinetic analysed the exposure to piperaquine i...
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Effect of DP mg/kg dosing strategies on the risk of treatment failureA pooled analysis to assess the impact of weight adjusted (mg/kg) dose variations...
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Determining the optimal Artemether-lumefantrine antimalarial dosing for young children and pregnant women: A pharmacokinetic-pharmacodynamic meta...
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Role of candidate molecular markers of lumefantrine and amodiaquine resistanceThe Artesunate-Amodiaquine/Artemether Lumefantrine (AS-AQ/AL) Molecular ...
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Analysing PK/PD data to identify inadequate drug exposure and inform antimalarial dosageA pooled pharmacokinetic/pharmacodynamics (PK/PD) analysis of ...
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A pooled analysis on the relationship between K13 molecular marker and parasite clearance data. The Study Group closed to new participants in Dec...
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Analysis of the consequences of symptomatic Plasmodium vivax infections on anaemia before and after antimalarial treatment