Data integration mathematical modelling for antimalarial drug resistance study group

Data integration mathematical modelling for antimalarial drug resistance study group

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Woman and daughter in hospital in Liberia
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Credit: Dominic Chavez, World Bank

The study group seeks to develop new methodologies for data integration of models for antimalarial drug resistance with disparate data sets.

Rationale

This project aims to develop new mathematical frameworks that integrate data from multiple sources to facilitate informed decisions in response to antimalarial drug resistance, namely parasite clearance data under treatment of an artemisinin combination therapy and K13 genetic marker data. The expected outcomes include enhanced capacity to predict changes in antimalarial drug resistance. 

Objectives

1: To advance data integration methods for antimalarial drug resistance.

2: To benchmark calibration methods for the new data integration models, where current techniques perform poorly.

Essential inclusion criteria

Patient linked data for parasite clearance over time under treatment with artemisinin and K13 genetic marker data. Data on treatment received, patient characteristics (and regression/summary variables such as age, sex, etc).

Specifically:

Parasitaemia

sid
site
pid

obsdate

dayofobs
hourofobs

pfbin

pfmicl

gfbin

gfmicl
 

Subject

sid

site

pid

obsdate

ageyears

gender

dateinc

hourinc

age
gender
 

Treatment

sid
site
pid 
treat

dayoftreat
houroftreat
 trt1
dos1
 trt2
dos2
 trt3
dos3

Molecular

sid
site
pid

obsdate

K13_WT_AnyMut
k13_87 -- k13_725 (e.g., all K13 mutation data)

Data Standardisation

Once all the data sets will be uploaded in the [WWARN, IDDO] Data Repository, according to the WWARN Clinical Data Management and Statistical Plan, they will be standardised and pooled into a single database of quality-assured individual patient data.

Study group governance and membership

The Study Group comprises participating investigators who contribute relevant data to the pooled analysis. Data will remain the property of the investigator. The Study Group collectively makes decisions with respect to including additional studies, data analysis and plans for publication, in line with the WWARN Publication Policy. The Study Group will identify one or two people to coordinate activities including data analysis, and drafting of publications and reports for group review. The study group statistician(s) will be responsible for statistical analyses.

For further information, please email: jennifer.flegg@unimelb.edu.au