Procedures

WWARN is continually updating a library of standardised procedures that offer guidance in the execution of various activities in the fields of clinical, in vitro, pharmacology, data collection and molecular analysis for antimalarial drug resistance researchers. Please read our tools and resources usage guidance.

For resources that relate to other infectious and emerging diseases, visit iddo.org.

Identifying critical suppliers of trial services

Author(s): WWARN

Estimation of Plasmodium falciparum drug susceptibility by the SYBR® Green assay

Publication Code: INV08

Drug susceptibility assay measuring SYBR®Green I fluorescence in laboratory strains and field isolates

Version: 1.0

Author(s): WWARN

msp2 PCR

Publication Code: EXT09

PCR amplification of the polymorphic marker msp2 to distinguish recrudescences from reinfections

Version: 1.0

Author(s): Mekong Molecular Surveillance Network

Collection of blood on filter paper

Publication Code: EXT01

Molecular Testing for Malaria - preparing dried blood spots by finger prick

Version: 1.0

Author(s): Mekong Molecular Surveillance Network

Emergency scenario training for clinical trial facilities

Publication Code: SAF04

A process for assuring competency in the emergency medical response provided by trial team members through emergency scenario training

Version: 2.0

Author(s): WWARN

glurp PCR

Publication Code: EXT06

PCR amplification of the polymorphic marker glurp to distinguish recrudescences from reinfections

Version: 1.0

Author(s): Mekong Molecular Surveillance Network

Quantification of Human and P. Falciparum DNA

Publication Code: MOL04

Estimating Plasmodium falciparum and human DNA concentration in infected blood samples by fluorometer and real-time PCR

Version: v1.0

Author(s): WWARN

Collection of blood by finger prick or heel stick

Publication Code: CL11

Obtaining fingerprick and heel stick blood samples for preparing thick/thin blood smears and filter paper samples

Version: 2.0

Author(s): WWARN

Management of hyperparasitaemia

Publication Code: CL06

A process for case management of patients with hyperparasitaemia in field malaria drug trials

Version: 1.0

Author(s): CCOAT

Collection of ECG data in antimalarial clinical trials

Publication Code: CL03

A general process for collecting the standard 12-lead clinical trial ECG data, to support any trial-specific instructions

Version: 1.2

Author(s): WWARN, Banook Group & LSTM