Study Groups
WWARN facilitates a number of collaborative Study Groups to undertake individual patient data meta-analyses to answer specific research questions about malaria treatments and antimalarial drug resistance. Gathering and combining data sets from multiple studies increases sample sizes, so that effects, including smaller effects, and effects on sub-populations can be identified with greater certainty. Working together and combining data from different regions and populations is improving our understanding of drug resistance and strengthening global efforts to control and eventually eliminate malaria.
![Dominic Chavez World Bank clinic_in_bamako](/sites/default/files/styles/standard_image_crop/public/page/clinic_in_bamako-dominic_chavezworld_bank.jpg?itok=D8rDR-D3)
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Dominic Chavez World Bank
![Woman holding baby](/sites/default/files/styles/research_activity_480x270/public/migrated/images/study-groups/flickr-dfid-mother-and-child-credit-_lindsay_mgbor_department_for_international_development.jpg?itok=lC75PbhT)
Exploring the impact of malaria during pregnancy on infant anaemia, malaria, morbidity and growth – an individual participant meta-analysis.
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Baseline information on parasitological response to ACTs in AsiaA pooled analysis to assess the baseline early parasitological response after artemisi...
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The Dihydroartemisinin-Piperaquine for Intermittent Preventive Treatment in Pregnancy Study Group aims to determine the safety and efficacy of intermi...
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Development of statistical methods to infer the relationship between the percentage of resistant infections, parasite clearance half-life and the prop...
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The Plasmodium vivax fever study group aims to estimate parasitaemia thresholds for febrile patients who present for treatment and determine the ...
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A meta-analysis of individual patient data (IPD) to determine the effect of antiretroviral (ARV) drug-drug interactions and HIV disease on artemether ...
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The sulphadoxine-pyrimethamine (SP) resistance Data Access Group’s aim is to provide maps and open access to the most recent data on molecular markers...
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![Pregnant woman sitting against a wall](/sites/default/files/styles/research_activity_480x270/public/migrated/images/study-groups/pregnant_woman-credit-doune_porter-gavi.jpg?itok=qdyVTfR6)
The Alternative MiP Prevention Strategies (AMPS) Study Group’s aim is to determine the safety and efficacy of novel strategies for the control of mala...
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Modelling the protective effect of Artesunate-Amodiaquine (AS-AQ)A pooled analysis to assess the post-treatment prophylactic effect of artesunate-amod...
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The First Trimester Safety of ACTs Study Group’s aim is to establish the evidence-base and safety profile to inform decision-making on the use of arte...
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Determining the effects of pregnancy on piperaquine pharmacokinetics. The analysis aims to contribute evidence needed to inform recommendations on the...
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The Sulphadoxine-Pyrimethamine (SP) resistance Study Group’s aim is to provide open access to, and establish maps with, the most recent data on SP res...
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![Dominic Chavez World Bank families stading together in Guinea](/sites/default/files/styles/research_activity_480x270/public/migrated/images/study-groups/families_standing_together_guinea_photo_dominic_chavez_world_bank.jpg?itok=jwEYgCH6)
Analysis of how age impacts the effect of primaquine dose on haematological safety in patients with Plasmodium vivax and Plasmodium ovale malaria
![Rumi Consultancy, World Bank Doctor treating baby who is held by father](/sites/default/files/styles/research_activity_480x270/public/migrated/images/study-groups/young_child_gets_checkup.credit_rumi_consultancy_world_bank.jpg?itok=XYl0YE4V)
Analysis of how age impacts the effect of primaquine dose on gastrointestinal tolerability in patients with Plasmodium vivax and Plasmodium ovale mala...
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This is an extension of the WWARN Haemoglobin-Haematocrit Relationship in Malaria Study Group and the Antimalarial–Antiretroviral Analy...
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![Credit Dominic Chavez, World Bank woman with child in Sierra Leone](/sites/default/files/styles/research_activity_480x270/public/2024-06/woman%20with%20child%20Sierra%20Leone%20credit%20Dominic%20Chavez%20World%20Bank.jpg?itok=ryBEKxCX)
The Study Group was formed in January 2024 to update and expand the WWARN work of the K13 Genotype-Phenotype Study Group, which was published in BMC M...
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The paediatric single low-dose (SLD) primaquine safety study group aims to describe and compare the safety of SLD primaquine for transmission blocking...
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Analysis of haematological response before and after antimalarial treatment. A pooled analysis to understand the normal haematological response a...
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![Photo Dominic Chavez, World Bank mothers and babies in health centre. Sierra Leone](/sites/default/files/styles/research_activity_480x270/public/2024-02/mothers%20and%20babies%20in%20health%20centre.%20Sierra%20Leone%20Photo%20Dominic%20Chavez%20World%20Bank.jpg?itok=u7MzyfqY)
This study group aims to determine the impact of malaria in the first trimester of pregnancy on the mother and infant through individual patient data ...
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Analysing PK/PD data to identify inadequate drug exposure and inform dosageA pooled piperaquine pharmacokinetic analysed the exposure to piperaquine i...
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Baseline information on parasitological response to ACTs in AfricaA pooled analysis to assess the baseline early parasitological response after artemi...
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Analysing PK/PD data to identify inadequate drug exposure and inform antimalarial dosageA pooled pharmacokinetic/pharmacodynamics (PK/PD) analysis of ...
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Analysis of risk factors of Plasmodium vivax early and late recurrence. Published in July 2018.
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A population pharmacokinetic/pharmacodynamic model of pyrimethamine and sulfadoxine in participants who received either sulfadoxine-pyrimethamine (SP)...
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Analysis of the consequences of symptomatic Plasmodium vivax infections on anaemia before and after antimalarial treatment
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Analysing PK/PD data to identify inadequate drug exposure and inform dosageA pooled lumefantrine pharmacokinetic-pharmacodynamic (PK/PD) analysis is b...
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Parasite clearance after treatment with an artemisinin monotherapy or ACTThis Study Group characterises parasite clearance stratified by location, tre...
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A pooled analysis that assessed the effect of various nutritional indicators in treatment outcome in children aged 6-59 months treated with artemisini...
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Effect of DP mg/kg dosing strategies on the risk of treatment failureA pooled analysis to assess the impact of weight adjusted (mg/kg) dose variations...
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Determining the optimal Artemether-lumefantrine antimalarial dosing for young children and pregnant women: A pharmacokinetic-pharmacodynamic meta...
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A pooled analysis of Plasmodium falciparum gametocyte carriageThe purpose of this Study Group is to assess the risk factors for treatment failure asso...
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Effect of AS-AQ mg/kg dosing strategies on the risk of treatment failureA pooled analysis to assess the impact of weight adjusted (mg/kg) dose variati...
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![children sitting on doorstep](/sites/default/files/styles/research_activity_480x270/public/migrated/images/study-groups/dsc_0390.jpg?itok=0AcvSXUF)
A pooled analysis on the relationship between K13 molecular marker and parasite clearance data. The Study Group closed to new participants in Dec...
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The AL Dose Impact Study Group was first established in 2011. The Study Group first met in December 2011 at the ASTMH Annual Meeting to discuss the St...
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Role of candidate molecular markers of lumefantrine and amodiaquine resistanceThe Artesunate-Amodiaquine/Artemether Lumefantrine (AS-AQ/AL) Molecular ...
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