Study Groups
WWARN facilitates a number of collaborative Study Groups to undertake individual patient data meta-analyses to answer specific research questions about malaria treatments and antimalarial drug resistance. Gathering and combining data sets from multiple studies increases sample sizes, so that effects, including smaller effects, and effects on sub-populations can be identified with greater certainty. Working together and combining data from different regions and populations is improving our understanding of drug resistance and strengthening global efforts to control and eventually eliminate malaria.
![Dominic Chavez World Bank clinic_in_bamako](/sites/default/files/styles/standard_image_crop/public/page/clinic_in_bamako-dominic_chavezworld_bank.jpg?itok=D8rDR-D3)
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Dominic Chavez World Bank
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Determining what affects White Blood Cell (WBC) count at baseline and during acute phase of malaria infection.
A pooled analysis of methaemoglobin as a marker of primaquine antihypnozoite activity in Plasmodium vivax malaria
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Analysis of how age impacts the effect of primaquine dose on gastrointestinal tolerability in patients with Plasmodium vivax and Plasmodium ovale mala...
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The Alternative MiP Prevention Strategies (AMPS) Study Group’s aim is to determine the safety and efficacy of novel strategies for the control of mala...
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This is an extension of the WWARN Haemoglobin-Haematocrit Relationship in Malaria Study Group and the Antimalarial–Antiretroviral Analy...
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Sub-study groups include the Artemether-Lumefantrine / ARV PK Study Group and the ACT-ARV Safety Study Group.
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Assessment of relationship between Haemoglobin (Hb) and Haematocrit (Hct) measurements.
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The Plasmodium vivax fever study group aims to estimate parasitaemia thresholds for febrile patients who present for treatment and determine the ...
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Assessing the efficacy of a range of antimalarials used for the treatment of P. falciparum malaria in all trimesters of pregnancy in Africa ...
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The Subpatent Malaria and Pregnancy Outcome Study Group aims to explore the relationship between subpatent Plasmodium falciparum malaria inf...
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This Study Group aims to bring together and explore the latest evidence on the prevalence of molecular markers associated with antimalarial drug resis...
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The Dihydroartemisinin-Piperaquine for Intermittent Preventive Treatment in Pregnancy Study Group aims to determine the safety and efficacy of intermi...
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The Alternative MiP Prevention Strategies (AMPS) Study Group’s aim is to determine the safety and efficacy of novel strategies for the control of mala...
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![Photo Dominic Chavez, World Bank mothers and babies in health centre. Sierra Leone](/sites/default/files/styles/research_activity_480x270/public/2024-02/mothers%20and%20babies%20in%20health%20centre.%20Sierra%20Leone%20Photo%20Dominic%20Chavez%20World%20Bank.jpg?itok=u7MzyfqY)
This study group aims to determine the impact of malaria in the first trimester of pregnancy on the mother and infant through individual patient data ...
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Analysis of haematological response before and after antimalarial treatment. A pooled analysis to understand the normal haematological response a...
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Analysis of the effect of primaquine dose on tolerability and Plasmodium vivax recurrence.
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A pooled analysis assessing the effect of mg/kg dosing strategies on the risk of treatment failure in patients treated with the currently recommended ...
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The Sulphadoxine-Pyrimethamine (SP) resistance Study Group’s aim is to provide open access to, and establish maps with, the most recent data on SP res...
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Determining the effects of pregnancy on piperaquine pharmacokinetics. The analysis aims to contribute evidence needed to inform recommendations on the...
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Analysing PK/PD data to identify inadequate drug exposure and inform antimalarial dosageA pooled pharmacokinetic/pharmacodynamics (PK/PD) analysis of ...
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Effect of AS-AQ mg/kg dosing strategies on the risk of treatment failureA pooled analysis to assess the impact of weight adjusted (mg/kg) dose variati...
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Analysing PK/PD data to identify inadequate drug exposure and inform dosageA pooled piperaquine pharmacokinetic analysed the exposure to piperaquine i...
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Role of candidate molecular markers of lumefantrine and amodiaquine resistanceThe Artesunate-Amodiaquine/Artemether Lumefantrine (AS-AQ/AL) Molecular ...
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A pooled analysis that assessed the effect of various nutritional indicators in treatment outcome in children aged 6-59 months treated with artemisini...
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Analysis of risk factors of Plasmodium vivax early and late recurrence. Published in July 2018.
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A pooled analysis on the relationship between K13 molecular marker and parasite clearance data. The Study Group closed to new participants in Dec...
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Parasite clearance after treatment with an artemisinin monotherapy or ACTThis Study Group characterises parasite clearance stratified by location, tre...
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Analysis of the consequences of symptomatic Plasmodium vivax infections on anaemia before and after antimalarial treatment
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A pooled analysis of Plasmodium falciparum gametocyte carriageThe purpose of this Study Group is to assess the risk factors for treatment failure asso...
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Determining the optimal Artemether-lumefantrine antimalarial dosing for young children and pregnant women: A pharmacokinetic-pharmacodynamic meta...
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Effect of DP mg/kg dosing strategies on the risk of treatment failureA pooled analysis to assess the impact of weight adjusted (mg/kg) dose variations...
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The AL Dose Impact Study Group was first established in 2011. The Study Group first met in December 2011 at the ASTMH Annual Meeting to discuss the St...
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Baseline information on parasitological response to ACTs in AfricaA pooled analysis to assess the baseline early parasitological response after artemi...
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Analysing PK/PD data to identify inadequate drug exposure and inform dosageA pooled lumefantrine pharmacokinetic-pharmacodynamic (PK/PD) analysis is b...
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A population pharmacokinetic/pharmacodynamic model of pyrimethamine and sulfadoxine in participants who received either sulfadoxine-pyrimethamine (SP)...
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