Challenges in antimalarial drug resistance

8th European Congress on Tropical Medicine and International Health, 2013 (ECTMIH-2013)

Friday, September 13, 2013 at the Congress Hall, Tivoli Congress Center, Copenhagen, Denmark 

11:15am – 12:45pm Session 1.5.4

Carol Hopkins Sibley, WWARN’s Scientific Director and Aimee Taylor, PhD Student working with WWARN at Oxford University will present during a symposium at the 8th European Congress on Tropical Medicine and International Health. A panel focused on the challenges in antimalarial drug resistance will provide an ideal platform for Carol Sibley to share our collective learning and experience of developing Study Group pooled analysis approaches that focus on establishing the treatment efficacy of Artemisinin Combination Therapies (ACTs) comprised of both the artemisinin derivative and the partner drug. The presentation will highlight the significance and value of pooling data from multiple studies and analysing  the resulting much larger data set to understand the effect of dosing regimens on the treatment efficacy of the  ACT partner drugs currently prescribed for patients suffering from uncomplicated malaria.

Aimee Taylor will share the highlights of her research using a Bayesian statistical analysis model designed to estimate P. falciparum antimalarial drug resistant genotype frequencies.  The model is a bio-informatics tool which enables investigators to make full use of data they have collected on prevalence of molecular markers, and therefore strengthen the molecular surveillance of antimalarial resistance. 

Let us know if you will be at ECTMIH so we can connect during the congress, in the meantime please find a brief summary of the symposia details below.

Challenges in antimalarial drug resistance

Chairperson:

Michael Alifrangis, University of Copenhagen, Denmark

Presentations:

Keynote: Cally Roper, London School of Tropical Medicine & Hygiene

“Active, prospective monitoring of antimalarial drug safety”, Piero Olliaro, WHO, Geneva, Switzerland

“Delayed parasite clearance after treatment with dihydroartemisinin-piperaquine in Plasmodium falciparum malaria patients in Central Vietnam”, Kamala Ley-Thriemer, Institute of Tropical Medicine, Antwerp, Belgium

“The effect of dosing regimens on the antimalarial efficacy of dihydroartemisinin piperaquine in patients diagnosed with uncomplicated malaria: a pooled analysis of individual patient data”, Carol Hopkins Sibley, WorldWide Antimalarial Resistance Network (WWARN)

“Statistical estimation of malaria genotype frequencies: a Bayesian approach”, Aimee Taylor, University of Oxford, Oxford, UK